METABOLIC MRI IS EMPOWERED BY HYPERPOLARIZATION. NVISION POLARIZERS MAKE IT SIMPLE.
Hyperpolarization enables rapid, precise measurement of natural metabolites. NVision provides fast, robust and easy-to-use hyperpolarization technology for preclinical and clinical research and clinical applications.
NVISION'S POLARIZER OFFERS:
High throughput (3min per dose)
Convenient, room temperature processing
Small footprint, no infrastructure adjustment
Simple, robust workflow
NVISION'S POLARIZER IS
BASED ON PHIP.
NVision is enabling room-temperature hyperpolarization in 3 minutes based on parahydrogen-induced polarization (PHIP) by combining deep expertise in spin quantum physics, chemistry and engineering.
The power source of PHIP is parahydrogen, a quantum state of hydrogen (singlet state), produced off-site and provided by NVision.
STEP 1
MANIPULATE SPIN-STATE CENTRALLY
Polarization is transferred to a natural metabolite by catalytically adding parahydrogen to a precursor.
STEP 3
TRANSFER POLARIZATION
Parahydrogen is stored in aluminum bottles and shipped to the users. NVision's technology ensures that parahydrogen stays stable for months.
STEP 2
SHIP TO USERS
After purification, the hyperpolarized metabolite, e.g. pyruvate, is ready for injection.
STEP 4
PURIFY AND RELEASE
ADVANCING IN ALL DIMENSIONS
With its unprecedented processing speed, robustness and ease of use, NVision provides first scalable solution that is compatible with clinical practice, while providing the same results as polarization devices based on dissolution dynamic nuclear polarization (dDNP).
dDNP state-of-the-art | NVISION | ||
|---|---|---|---|
Polarization | > 10 % polarization at time of injection | = | > 10 % polarization at time of injection |
Process speed | Low throughput (>120 minutes per dose)
Additional hours of
advanced preparations | ↗ | High throughput (3 minutes per dose) |
Robustness | Operates at extremely low temperatures (< 1 K) | ↗ | Operates at room temperature, designed for robustness and minimal failure rate |
Ease of use | Large footprint, requires complex compounding operations and utilities | ↗ | Small & versatile, no room adjustment, single operator and user-friendly interface |
NVISION PHIP AND STATE-OF-THE-ART dDNP PROVIDE COMPARABLE RESULTS IN PRECLINICAL EXPERIMENTS
Example of metabolic imaging: pyruvate to lactate conversion (dynamic CSI)
PHIP
dDNP
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