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METABOLIC MRI IS EMPOWERED BY HYPERPOLARIZATION.
NVISION MAKES IT SIMPLE.

Hyperpolarization enables rapid, precise measurement of natural metabolites. NVision provides fast, robust and easy-to-use hyperpolarization technology for preclinical and clinical research and clinical applications.

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POLARIS OFFERS:

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High throughput (3min per dose)

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Convenient, room temperature processing

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Small footprint, no infrastructure adjustment

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Simple, robust workflow

Preclinical POLARIS delivery from 2024

Clinical POLARIS following in 2025

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POLARIS IS
BASED ON PHIP.

NVision is enabling room-temperature hyperpolarization in 3 minutes based on parahydrogen-induced polarization (PHIP) by combining deep expertise in spin quantum physics, chemistry and engineering.

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The power source of PHIP is parahydrogen, a quantum state of hydrogen (singlet state), produced off-site and provided by NVision.

STEP 1
MANIPULATE SPIN-STATE CENTRALLY

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Polarization is transferred to a natural metabolite by catalytically adding parahydrogen to a precursor.

STEP 3
TRANSFER POLARIZATION

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Parahydrogen is stored in aluminum bottles and shipped to the users. NVision's technology ensures that parahydrogen stays stable for months.

STEP 2
SHIP TO USERS

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After purification, the hyperpolarized metabolite, e.g. pyruvate, is ready for injection.

STEP 4
PURIFY AND RELEASE

POLARIS FOR PRECLINICAL USE

NVISION PROVIDES AN END-TO-END SOLUTION, ENABLING FAST RAMP-UP
IN YOUR LAB.

POLARIZER

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CONSUMABLES

Active ingredients
Ready to use 13C-pyruvate precursor and catalyst

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Parahydrogen cylinders

SUPPORT

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Service
Maintenance
Training
Consulting
Research Collaboration

DOSE PRODUCTION IN THREE SIMPLE STEPS

TECHNICAL SPECIFICATIONS

13C-Pyruvate

Probe

>15% at injection

Polarization

3 options available: (a) 0.8 mL at 80 mM, (b) 1 mL at 160mM, (c) 2 mL at 80 mM

Produced dose

3 minutes for dose production, 10 minutes dose interval (incl. cleaning)

Process Time

Integrated fluidic control, no manual manipulation required, semi-automated cleaning after each dose

Fluidic control

13C-pyruvate precursor
Parahydrogen gas in multi-dose standard cylinder

Consumables
Supplied by NVision

Standard reagents (NVision supports purchasing)
N   in a standard cylinder or wall outlet

2

Other Consumables

Height < 195 cm // Weight < 350 kg // Footprint < 1 m

2

Dimensions

Fits in standard elevators, can be wheeled between rooms

Transportability

Standard power supply, installation outside of 5 G line

Installation

Certifications

Fulfills relevant US / EU certifications for laboratory equipment

* subject to change

NVISION'S POLARIZATION PLATFORM PROVIDES EXCELLENT DATA IN UNPRECEDENTED THROUGHPUT AND ROBUSTNESS.

COMPARISON OF PHIP / d-DNP SPECTROSCOPY

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MATBIII model (Rat)

Integrated signal intensities over time from dynamic spectroscopy of a slice containing only the tumor of a subcutaneous MATBIII model (Rat).

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EL4 lymphoma model (Mouse)

Integrated signal intensities over time from dynamic spectroscopy of a slice containing only the tumor of a subcutaneous EL4 lymphoma model (Mouse).

Wolfgang Gottwald, Department of Nuclear Medicine, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.

COMPARISON OF PHIP / d-DNP IMAGING

Luca Nagel, Department of Nuclear Medicine, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany

NEW APPLICATIONS ARE NOW ENABLED BY FAST DOSE PRODUCTION (4 INJECTIONS WITHIN 1 HOUR).

Wolfgang Gottwald, Department of Nuclear Medicine, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany.

MATBIII breast cancer model (Rat)

Dynamic spectroscopy of tumor slice after four injections of PHIP pyruvate.
Pyruvate peaks normalized to 1.

FOR MORE INFORMATION
CONNECT WITH US.

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FEATURES IN LEADING JOURNALS
AND PRESS RELEASES

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